selected publications

1. Xu D^#, Feng Z^#, Hou WT, Jiang YL, Wang L, Sun LF*, Zhou CZ*, Chen Y*. Cryo-EM structure of human lysosomal cobalamin exporter ABCD4. Cell Research. 29(12):1039-1041. doi: 10.1038/s41422-019-0222-z.
   

2. Jin H^#, Jiang YL^#, Yang F, Zhang JT, Li WF, Zhou K, Ju J, Chen Y*, Zhou CZ*. Capsid structure of a freshwater cyanophage Siphoviridae Mic1. Structure. 27(10):1508-1516. doi: 10.1016/j.str.2019.07.003.
   

3. Zhang CC, Zhou CZ, Burnap RL, Peng L. Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria. Trends in Plant Science. 2018 Oct 3; TRPLSC 1733 No. of Pages 15.

4. Yang HB^#, Hou WT^#, Cheng MT^#, Jiang YL*, Chen Y*, Zhou CZ*. Structure of a MacAB-like efflux pump from Streptococcus pneumoniae. Nature Communications. 2018 January; 9(1):196.
   

5. Jiang YL^#, Wang XP^#, Sun H^#, Han SJ, Li WF, Cui N, Li GM, Zhang JY, Cheng W, Cao DD, Zhang ZY, Zhang CC*, Chen Y*, Zhou CZ*. Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proceedings of the National Academy of Sciences USA. 2018 January; 115(2):403-408.  

6. Jiang YL^#, Jin H^#, Yang HB, Zhao RL, Wang SL, Chen Y*, Zhou CZ*. Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. Journal of Biological Chemistry. 2017 Feb; 292(15):6213-6224.

7. Xie J, Cai K, Hu HX, Jiang YL, Yang F, Hu PF, Cao DD, Li WF, Chen Y*, Zhou CZ*. Structural analysis of the catalytic mechanism and substrate specificity of Anabaena alkaline invertase InvA reveals a novel glucosidase. Journal of Biological Chemistry. 2016 Oct; 291(49):25667-25677.
   

8. Cao LX^#, Huang Q^#, Wu ZC^#, Cao DD^#, Ma ZL^#, Xu QH, Hu P, Fu YX, Shen Y, Chan JL, Zhou CZ, Zhai WY, Chen LB*. Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids. Nature Communications. 2016 Oct; 7:12987.

9. Yu LY^#, Cheng W^#, Zhou K^#, Li WF, Yu HM, Gao X, Shen X, Wu Q, Chen Y*, Zhou CZ*. Structures of an all-α protein running along the DNA major groove. Nucleic Acids Research. 2016 Mar; 44(8): 3936–3945. 

10. Wang XP, Jiang YL, Dai YN, Cheng W, Chen Y*, Zhou CZ*. Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis. Glycobiology. 2016 May; 26(5): 520-31. 

11. Jia N, Liu N, Cheng W, Jiang YL, Sun H, Chen LL, Peng J, Zhang Y, Ding YH, Zhang ZH, Wang X, Cai G, Wang J, Dong MQ, Zhang Z, Wu H, Wang HW*, Chen Y*, Zhou CZ*. Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO Reports. 2016 Feb; 17(2): 235-48. 

12. Bai XH^#, Chen HJ^#, Jiang YL, Wen Z, Huang Y, Cheng W, Li Q, Qi L, Zhang JR*, Chen Y*, Zhou CZ*. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. Journal of Biological Chemistry. 2014 Aug; 289(34): 23403-16.

13. Shi WW^#, Jiang YL^#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-GlcNAc transferase GtfA reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. Journal of Biological Chemistry. 2014 Jul; 289(30): 20898-907.

14. Yang YH^#, Jiang YL^#, Zhang J, Wang L, Bai XH, Zhang SJ, Ren YM, Li N, Zhang YH, Zhang Z, Gong Q, Mei Y, Xue T, Zhang JR, Chen Y*, Zhou CZ*. Structural insights into SraP-mediatedStaphylococcus aureusadhesion to host cells. PLoS Pathogens. 2014 Jun; 10(6): e1004169.

15. Tang Y, Zhang J, Yu J, Xu L, Wu J, Zhou CZ*, Shi Y*. Structure-guided activity enhancement and catalytic mechanism of yeast Grx8. Biochemistry. 2014 Apr; 53(13): 2185-96.

16. Zhang CC*, Zhou CZ. ATPase as a switch in PII signal transduction (COMMENTARY). Proceedings of the National Academy of Sciences USA. 2013 Aug; 110(32): 12863-4.

17. Dai YN, Chi CB, Zhou K, Cheng W, Jiang YL, Ren YM, Ruan K, Chen Y, Zhou CZ*. Structure and catalytic mechanism of yeast 4-amino-4-deoxychorismate lyase. Journal of Biological Chemistry. 2013 Aug; 288(32): 22985-92.

18. Hou WT, Li WZ, Chen Y, Jiang YL*, Zhou CZ*. Structures of yeast Apa2 reveal catalytic insights into a canonical Ap₄A phosphorylase of the histidine triad superfamily. Journal of Molecular Biology. 2013 Aug; 425(15): 2687-98.

19. Yu WL, Jiang YL, Pikis A, Cheng W, Bai XH, Ren YM, Thompson J, Zhou CZ*, Chen Y*. Structural insights into the substrate specificity of a 6-phospho-β-glucosidase BglA-2 fromStreptococcus pneumoniaeTIGR4. Journal of Biological Chemistry. 2013 May; 288(21): 14949-58.

20. Guo PC, Ma JD, Jiang YL, Wang SJ, Bao ZZ, Yu XJ, Chen Y, Zhou CZ*. Structure of yeast sulfhydryl oxidase Erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space. Journal of Biological Chemistry. 2012 Oct; 287(42): 34961-9.

21. Cheng W^#, Wang L^#, Jiang YL, Bai XH, Chu J, Li Q, Yu G, Liang QL, Zhou CZ*, Chen Y*. Structural insights into the substrate specificity ofStreptococcus pneumoniaeβ(1,3)-galactosidase BgaC. Journal of Biological Chemistry. 2012 Jun; 287(27): 22910-8.

22. Lian FM, Yu J, Ma XX, Yu XJ, Chen Y, Zhou CZ*. Structural snapshots of yeast Alkyl hydroperoxide reductase Ahp1 peroxiredoxin reveal a Novel 2-cysteine mechanism of electron transfer to eliminate reactive oxygen species. Journal of Biological Chemistry. 2012 May; 287(21): 17077-87.

23. He YX^#, Zhang NN^#, Li WF, Jia N, Chen BY, Zhou K, Zhang JH, Chen Y, Zhou CZ*. N-terminal domain ofBombyx morifibroin mediates the assembly of silk in response to pH decrease. Journal of Molecular Biology. 2012 May; 418(3-4): 197-207.

24. Jiang YL^#, Yu WL^#, Zhang JW, Frolet C, Di Guilmi AM, Zhou CZ, Vernet T*, Chen Y*. Structural basis for the substrate specificity of a novel β-N-acetyl-hexosaminidase StrH protein fromStreptococcus pneumoniae R6. Journal of Biological Chemistry. 2011 Dec; 286(50): 43004-12.

25. Jiang YL^#, Zhang JW^#, Yu WL, Cheng W, Zhang CC, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ*, Chen Y*. Structural and enzymatic characterization of theStreptococcalATP/Diadenosine polyphosphate and phosphodiester hydrolase Spr1479/SapH. Journal of Biological Chemistry. 2011 Oct; 286(41): 35906-14.

26. Guo PC, Ma XX, Bao ZZ, Ma JD, Chen Y, Zhou CZ*. Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1. Journal of Structural Biology. 2011 Oct; 176: 112-8.

27. Chen BY^#, Ma XX^#, Guo PC, Tan X, Li WF, Yang JP, Zhang NN, Chen Y, Xia Q, Zhou CZ*. Structure-guided activity restoration of the silkworm glutathione transferase omega GSTO3-3. Journal of Molecular Biology. 2011 Sep; 412(2): 204-11.

28. Pu YG, Jiang YL, Ye XD, Ma XX, Guo PC, Lian FM, Teng YB, Chen Y, Zhou CZ*. Crystal structures and putative interface ofSaccharomyces cerevisiaemitochondrial matrix proteins Mmf1 and Mam33. Journal of Structural Biology. 2011 Sep; 175(3): 469-74.

29. Ma G, Yu J, Xiao Y, Chan D, Gao B, Hu J, He Y, Guo S, Zhou J, Zhang L, Gao L, Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L*. Indian hedgehog mutations causing brachydactyly type A1 impair hedgehog signal transduction at multiple levels. Cell Research. 2011 Sep; 21(9): 1343-57.

30. Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y*, Zhou CZ*. Crystal structure of the 30K protein from the silkwormBombyx morireveals a new member of the β-trefoil superfamily. Journal of Structural Biology. 2011 Jul; 175(1): 97-103.

31. Du Y^#, Shi WW^#, He YX, Yang YH, Zhou CZ*, Chen Y*. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities ofBacillus subtilisABC transporter OpuC. Biochemical Journal. 2011 Jun; 436(2): 283-9.

32. Ma XX, Guo PC, Shi WW, Luo M, Tan XF, Chen Y, Zhou CZ*. Structural plasticity of the thioredoxin recognition site of yeast methionine-S-sulfoxide reductase Mxr1. Journal of Biological Chemistry. 2011 Apr; 286(15): 13430-7.

33. Du Y, He YX, Zhang ZY, Yang YH, Shi WW, Frolet C, Guilmi AM, Vernet T, Zhou CZ, Chen Y*. Crystal structure of the mucin-binding domain of Spr1345 fromStreptococcus pneumoniae. Journal of Structural Biology. 2011 Apr; 174(1): 252-7.

34. Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y, Zhou CZ*. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochemical Journal. 2010 Dec; 432(3): 445-50.

35. Zhao MX^#, Jiang YL^#, Xu BY, Chen Y, Zhang CC, Zhou CZ*. Crystal structure of cyanobacterial signal transduction protein PII in complex with PipX. Journal of Molecular Biology. 2010 Sep; 402(3): 552-9.

36. Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC*, Zhou CZ*. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proceedings of the National Academy of Sciences USA. 2010 Jul; 107(28): 12487-92.

37. Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, Zhou CZ*. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. Journal of Molecular Biology. 2010 May; 398(4): 614-22.

38. Deville-Bonne D*, El Amri C, Meyer P, Chen Y, Agrofoglio LA, Janin J. Human and viral nucleoside/nucleotide kinases involved in antiviral drug activation: structural and catalytic properties. Antiviral Research. 2010 Apr; 86(1): 101-20.

39. He YX^#, Huang L^#, Xue Y^#, Fei X, Teng YB, Rubin-Pitel S, Zhao H*, Zhou CZ*. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG fromPseudomonas fluorescens. Journal of Biological Chemistry. 2010 Feb; 285(7): 4603-11.

40. Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ*. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Reports. 2009 Dec; 10(12): 1320-6.

41. Bao R, Zhou CZ, Jiang C, Lin SX, Chi CW*, Chen Y*. The Ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. Journal of Biological Chemistry. 2009 Sep; 284(39): 26676-84.

42. Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U*. Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX. Journal of Biological Chemistry. 2006 Aug; 281: 24048-57.

43. Graille M^#, Zhou CZ^#, Receveur V, Collinet B, Declerck N, van Tilbeurgh H*. Activation of the LicT transcriptional antiterminator involves a domain Swing/Lock mechanism provoking massive structural changes. Journal of Biological Chemistry. 2005 Apr; 280(15): 14780-9.

44. Liger D, Graille M, Zhou CZ, Leulliot N, Quevillon-Cheruel S, Blondeau K, Janin J, van Tilbeurgh H*. Crystal structure and functional characterisation of yeast YLR011wp, an enzyme with NAD(P)H-FMN and ferric iron reductase activities. Journal of Biological Chemistry. 2004 Aug; 279: 34890-7.

45. Graille M, Cheruel S, Leulliot N, Zhou CZ, Li de La Sierra Gallay I, Jacquamet L, Ferrer J-L, Poupon A, Janin J, van Tilbeurgh H*. Crystal structure of the YDR533cS. cerevisiaeProtein, a Class II member of the Hsp 31 family. Structure. 2004 May; 12: 839-47.

46. Zhou CZ, de la Sierra-Gallay IL, Quevillon-Cheruel S, Collinet B, Graille M, Blondeau K, Leulliot N, Sorel I, Poupon A, Janin J, van Tilbeurgh H*. Crystal structure of the yeast PX-domain protein Grd19p complexed to phosphatidylinositol-3-phosphate. Journal of Biological Chemistry. 2003 Dec; 278: 50371-6.

47. Chen Y, Gallois-Montbrun S, Schneider B, Véron M, Moréra S, Deville-Bonne D, Janin J*. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. Journal of Molecular Biology. 2003 Sep; 332(4): 915-26.

48. Gallois-Montbrun S, Schneider B, Chen Y, Giacomoni-Fernandes V, Mulard L, Morera S, Janin J, Deville-Bonne D*, Veron M. Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation. Journal of Biological Chemistry. 2002 Oct; 277(42): 39953-9.

49. Zhou CZ, Confalonieri F*, Medina N, Esnault C, Zivanovic Y, Yang T, Jacquet M, Janin J, Duguet M, Perasso R, Li ZG. Fine organization ofBombyx morifibroin heavy chain gene. Nucleic Acids Research. 2000 Jun; 28(12): 2413-9.